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KMID : 0614620200760050256
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Korean Journal of Gastroenterology
2020 Volume.76 No. 5 p.256 ~ p.260
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Seroreversion and Acute Decompensation in Chronic Hepatitis B after Discontinuation of Oral Nucleotide Analog in the Patients Achieving HBsAg Loss
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Cho Hye-Jeong
Shin Seung-Kak
Kwon Oh-Sang
Kim Ju-Hyun
Kim Yun-Soo
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Abstract
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Although rare patients with chronic hepatitis B can achieve HBsAg loss on oral nucleos(t)ide analog (NA), the optimal timing of stopping oral NAs safely has been considered when HBsAg and HBV DNA are negative in the serum because HBsAg loss induced by nucleos(t)ide analogs (NAs) appears to be durable if immunosuppressive therapy or chemotherapy are not done. On the other hand, the author experienced a case of HBsAg seroreversion and acute decompensation after the discontinuation of NA in a patient with HBsAg loss. This rare case highlights the need for the close monitoring of patients who achieved HBsAg loss and stopped NA.
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KEYWORD
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Hepatitis B virus, Functional cure, HBsAg loss, HBsAg reversion, Nucleos(t)ide analogues
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